Page 12 - Delaware Medical Journal - December 2015
P. 12
CANCER CLINICAL TRIAL
NCI PROTOCOL OF THE MONTH
ECOG E4112: Prospective Study of Magnetic Resonance Imaging (MRI) and Multiparameter Gene Expression Assay in Ductal Carcinoma In Situ (DCIS)
The objectives of the trial are:
Primary Objective:
To estimate the proportion of patients with DCIS diagnosed on core needle biopsy judged to be breast conservation candidates based upon standard
Secondary Objectives:
To estimate the proportion of patients who proceed to mastectomy after an initial attempt at wide local excision because of either inadequate
To estimate the 5-year and 10-year ipsilateral breast event (in situ and invasive) rate (IBE) among women with DCIS assessed with MRI
preoperatively and treated with wide local excision without radiation therapy (if there is a low DCIS score) or with radiation therapy (if there is an
To estimate the proportion of women with DCIS whose decision autonomy preference was concordant with perceived level of decision
Eligibilty:
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• Bilateral screening mammogram within 6 months of registration and diagnostic mammogram of the affected breast within 3 months of
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Treatment:
Step 1:
Step 2:
Step 3:
For information regarding clinical trials
or if you would like to have the list of open protocols e-mailed to you, akee@christianacare.org.
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Del Med J | December 2015 | Vol. 87 | No. 12
